The Three Worst Houston Freeway Interchanges
1. Highway 288, U.S. 59 and Interstate 45
And still, nothing compares to the nightmare where Texas Highway 288, U.S. 59 and Interstate 45 intersect. In addition to elevated portions of 45 and 59, massive traffic in and around the Medical Center, the dangerous exit to Spur 527 off 59 just before you reach this confluence, you have a bizarre almost subterranean feel to stretches of 59 between 288 and 45 that are as claustrophobic as they are jammed with people.
With so many exits pushing and pulling drivers all over the highway along this lower level of highway, it's a miracle anyone ever gets to their intended destination. Frankly, I wouldn't be surprised if someone trying to get to the University of Houston ends up near the Ship Channel weeping and hoping their cell phone doesn't die before help arrives. It doesn't help that drivers here often act like their only job is to avoid any possible slow down, whipping in and out of lanes to find the fastest route to Galveston.
My best advice if you cannot avoid this area is to read many maps carefully. Become a cartographer if you must, but don't drive here unless you know what you are doing and even then, a prayer couldn't hurt.